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SEMO Baseball 2021 Schedule
| February 19, 2021 (Friday) | 3:00 PM | South Alabama |
| February 20, 2021 (Saturday) | 2:00 PM | South Alabama |
| February 21, 2021 (Sunday) | 1:00 PM | South Alabama |
| February 25, 2021 (Thursday) | 3:00 PM | Arkansas |
| February 26, 2021 (Friday) | 3:00 PM | Arkansas |
| February 27, 2021 (Saturday) | 3:00 PM | Arkansas |
| February 28, 2021 (Sunday) | 1;00 PM | Arkansas |
| March 5, 2021 (Friday) | 3:00 PM | Illinois State |
| March 6, 2021 (Saturday) | 12:00 PM | Illinois State |
| March 6, 2021 (Saturday) | 3:00 PM | Illinois State |
| March 7, 2021 (Sunday) | 1:00 PM | Illinois State |
| March 12, 2021 (Friday) | 4:00 PM | SIU Edwardsville |
| March 13, 2021 (Saturday) | 1:00 PM | SIU Edwardsville |
| March 13, 2021 (Saturday) | 4:00 PM | SIU Edwardsville |
| March 16, 2021 (Tuesday) | 3:00 PM | Saint Louis |
| March 19, 2021 (Friday) | 5:00 PM | Austin Peay |
| March 20, 2021 (Saturday) | 2:00 PM | Austin Peay |
| March 20, 2021 (Saturday) | 5:00 PM | Austin Peay |
| March 23, 2021 (Tuesday) | 5:00 PM | Southern Illinois |
| March 26, 2021 (Friday) | 3:00 PM | Eastern Illinois |
| March 27, 2021 (Saturday) | 11:30 AM | Eastern Illinois |
| March 27, 2021 (Saturday) | 2:30 PM | Eastern Illinois |
| March 30, 2021 (Tuesday) | 5:00 PM | Missouri State |
| April 2, 2021 (Friday) | 5:00 PM | Jacksonville State |
| April 3, 2021 (Saturday) | 2:00 PM | Jacksonville State |
| April 3, 2021 (Saturday) | 5:00 PM | Jacksonville State |
| April 9, 2021 (Friday) | 5:00 PM | Murray State |
| April 10, 2021 (Saturday) | 2:00 PM | Murray State |
| April 10, 2021 (Saturday) | 5:00 PM | Murray State |
| April 13, 2021 (Tuesday) | 5:00 PM | UT Martin |
| April 16, 2021 (Friday) | 5:00 PM | Tennessee Tech |
| April 17, 2021 (Saturday) | 2:00 PM | Tennessee Tech |
| April 17, 2021 (Saturday) | 5:00 PM | Tennessee Tech |
| April 23, 2021 (Friday) | 6:30 PM | Missouri State |
| April 24, 2021 (Saturday) | 1:00 PM | Missouri State |
| April 24, 2021 (Saturday) | 4:00 PM | Missouri State |
| April 25, 2021 (Sunday) | 1:00 PM | Missouri State |
| April 28, 2021 (Wednesday) | 3:00 PM | Austin Peay |
| April 30, 2021 (Friday) | 4:00 PM | Belmont |
| May 1, 2021 (Saturday) | 1:00 PM | Belmont |
| May 1, 2021 (Saturday) | 4:00 PM | Belmont |
| May 7, 2021 (Friday) | 5:00 PM | Eastern Kentucky |
| May 8, 2021 (Saturday) | 2:00 PM | Eastern Kentucky |
| May 8, 2021 (Saturday) | 5:00 PM | Eastern Kentucky |
| May 14, 2021 (Friday) | 1:00 PM | Morehead State |
| May 15, 2021 (Saturday) | 1:00 PM | Morehead State |
| May 15, 2021 (Saturday) | 4:00 PM | Morehead State |
| May 20, 2021 (Thursday) | 5:00 PM | UT Martin |
| May 21, 2021 (Friday) | 2:00 PM | UT Martin |
| May 21, 2021 (Friday) | 5:00 PM | UT Martin |
| May 27, 2021 (Thursday) | TBA | OVC Tournament |
| May 28, 2021 (Friday) | TBA | OVC Tournament |
| May 29, 2021 (Saturday) | TBA | OVC Tournament |