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2020 – 2021 SEMO Women’s Basketball Schedule
| November 25, 2020 (Wednesday) | 2:00 PM | Home | #5 Louisville |
| December 1, 2020 (Tuesday) | 6:30 PM | Home | University of Health Sciences & Pharmacy |
| December 6, 2020 (Sunday) | 2:00 PM | Home | Eastern Michigan |
| December 11, 2020 (Friday) | 6:30 PM | Home | Western Illinois |
| December 13, 2020 (Sunday) | 2:00 PM | Away | Southern Illinois |
| December 19, 2020 (Saturday) | 2:00 PM | Home | UT Martin |
| December 30, 2020 (Wednesday) | 5:00 PM | Away | Tennessee Tech |
| January 2, 2021 (Saturday) | 2:00 PM | Home | Tennessee State |
| January 7, 2021 (Thursday) | 4:00 PM | Away | Belmont |
| January 9, 2021 (Saturday) | 1:00 PM | Away | Tennessee State |
| January 14, 2021 (Thursday) | 5:00 PM | Home | Murray State |
| January 16, 2021 (Saturday) | 2:00 PM | Home | Austin Peay |
| January 21, 2021 (Thursday) | 3:00 PM | Away | Morehead State |
| January 23, 2021 (Saturday) | 12:00 PM | Away | Eastern Kentucky |
| January 28, 2021 (Thursday) | 5:00 PM | Home | SIU Edwardsville |
| January 30, 2021 (Saturday) | 2:00 PM | Home | Eastern Illinois |
| February 1, 2021 (Monday) | 7:00 PM | Away | UT Martin |
| February 4, 2021 (Thursday) | 5:00 PM | Home | Tennessee Tech |
| February 6, 2021 (Saturday) | 2:00 PM | Home | Jacksonville State |
| February 11, 2021 (Thursday) | 4:30 PM | Away | Murray State |
| February 13, 2021 (Saturday) | 1:00 PM | Away | Austin Peay |
| February 18, 2021 (Thursday) | 5:00 PM | Home | Eastern Kentucky |
| February 19, 2021 (Friday) | 5:00 PM | Home | Morehead State |
| February 25, 2021 (Thursday) | 4:30 PM | Away | Eastern Illinois |
| February 27, 2021 (Saturday) | 1:00 PM | Away | SIU Edwardsville |
| March 3, 2021 (Wednesday) | TBA | First Round | |
| March 4, 2021 (Thursday) | TBA | Quarterfinals | |
| March 5, 2021 (Friday) | TBA | Semifinals | |
| March 6, 2021 (Saturday) | TBA | Championship |